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PHENOMENON OR PROCESS
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NATURAL PHENOMENON OR PROCESS
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BIOLOGICAL PHENOMENON
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genetic processes
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DNA damage
PREFERRED TERM
DNA damage
TYPE
Topic
DEFINITION
Daño producido por medicamentos o radiación al ADN que producen anormalidades en su conformación de doble hélice.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a mutation or a block of DNA replication. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (pyrimidine dimers) or interstrand crosslinking. Damage can often be repaired. If the damage is extensive, it can induce apoptosis.
BROADER CONCEPT
genetic processes
RELATED CONCEPTS
DNA fragmentation
DNA repair
genotoxicity
mutation
ALTERNATIVE LABEL
DNA injury
BELONGS TO GROUP
genetics
IN OTHER LANGUAGES
daño al ADN
Spanish
URI
http://id.agrisemantics.org/gacs/C7740
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EXACT MATCH
http://lod.nal.usda.gov/nalt/34181
lod.nal.usda.gov